Boron tribromide → HCID 58764013、化合物
反応式
C[O:2][C:3]1[C:8]([CH2:9][C:10]([F:13])([F:12])[F:11])=[CH:7][CH:6]=[CH:5][C:4]=1[CH3:14].B(Br)(Br)Br>ClCCl>[CH3:14][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([CH2:9][C:10]([F:11])([F:12])[F:13])[C:3]=1[OH:2]参加物
4
実験手順
2-Methoxy-1-methyl-3-(2,2,2-trifluoro-ethyl)-benzene(6.0 g) was dissolved in dichloromethane (100 ml) and BBr3 (100 ml) added. The reaction was allowed to stir at room temperature for 12 hrs, after which time it was quenched slowly with cHCl. The mixture was then made basic with 2N NaOH solution and the organics discarded. The aqueous was acidified with 1N HCl and the product extracted with ethyl acetate to afford the title compound as a brown oil (4.43 g). LCMS: APCI−VE=189
後処理
- customafter which time it was quenched slowly with cHCl
- extractionthe product extracted with ethyl acetate
出典と根拠
- ORDレコード
- ord-dfa72256d841480a928a3b08edc351d0
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07622605B2
反応ノート
読み込み中…