Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile

反応式

[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 8082Piperidine

HCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

生成物 1

HCID 588735266-tert-Butyl-2-piperidin-1-ylnicotinonitrile収率 98%

実験手順

A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).

後処理

customThen the reaction mixture was evaporated
customto remove piperidine in vacuo

出典と根拠

ORDレコード: ord-80d446bf3b074083b1f562d054f90ae1
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07622589B2

反応ノート

読み込み中…

参加物