Sulfuric Acid → 9-carboxy-11H-pyrrolo[2,1-b][3]benzazepin-11-one
反応式
[C:1]([C:4]1[CH:18]=[CH:17][C:7]2[CH:8]=[CH:9][N:10]3[CH:16]=[CH:15][CH:14]=[C:11]3[C:12](=[O:13])[C:6]=2[CH:5]=1)(=[O:3])N.S(=O)(=O)(O)[OH:20].N([O-])=O.[Na+]>O>[C:1]([C:4]1[CH:18]=[CH:17][C:7]2[CH:8]=[CH:9][N:10]3[CH:16]=[CH:15][CH:14]=[C:11]3[C:12](=[O:13])[C:6]=2[CH:5]=1)([OH:20])=[O:3]参加物
5
実験手順
To 9-carbamoyl-11H-pyrrolo[2,1-b] [3]-benzazepin-11-one (27 g., 0.112 moles) in 300 ml. of 50% sulfuric acid maintained at 50° C. is added slowly 25 g. of sodium nitrite in 75 ml. of water. At the end of the addition, the solid is filtered, washed with water and air-dried to yield 9-carboxy-11H-pyrrolo[2,1-b] [3]benzazepin-11-one.
後処理
- additionis added slowly 25 g
- additionAt the end of the addition
- filtrationthe solid is filtered
- washwashed with water
- customair-dried
出典と根拠
- ORDレコード
- ord-e64f585b0fda4b16899fd10e750d30b4
- 出典データセット
- uspto-grants-1977_11
- 特許番号
- US04056536
反応ノート
読み込み中…