Sulfuric Acid → HCID 54345768、化合物

反応式

S(=O)(=O)(O)O.[CH2:6]([O:8][C:9](=[O:19])[C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([NH2:17])[C:11]=1[Cl:18])[CH3:7].O[CH2:21][S:22]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=1)(=[O:24])=[O:23]>O>[CH2:6]([O:8][C:9](=[O:19])[C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([NH:17][CH2:21][S:22]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)(=[O:24])=[O:23])[C:11]=1[Cl:18])[CH3:7]

参加物

実験手順

1 g of concentrated sulfuric acid was added to 2.32 g (10mmoles) of 2,5-dichloro-3-aminobenzoic acid ethyl ester, 2.27 g (11mmoles) of hydroxymethyl-(4-chlorophenyl)-sulfone and 40 ml of water whilst stirring at room temperature. The mixture was stirred for a further 3 hours at room temperature, the solid was filtered off and dissolved in about 100 ml of methylene chloride, the solution was dried over magnesium sulfate and worked up in the usual manner and the product was recrystallized from ethylene chloride. 3.0 g (71% of theory) of 2,5-dichloro-3-[(4-chlorophenyl)-sulfonylmethylamino]-benzoic acid ethyl ester were obtained in the form of colorless crystals of melting point 173°-175° C.