Sodium Bicarbonate → 2-(3-Acetyl-4-hydroxyphenyl)propan-1-ol

HRID 1438980

反応式

HRID 1438980 の反応式
C([O:4][CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([C:15](=[O:17])[CH3:16])[CH:9]=1)[CH3:7])(=O)C.C(=O)(O)[O-].[Na+]>C(O)C.O>[C:15]([C:10]1[CH:9]=[C:8]([CH:6]([CH3:7])[CH2:5][OH:4])[CH:13]=[CH:12][C:11]=1[OH:14])(=[O:17])[CH3:16]

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 213220012-(3-Acetyl-4-hydroxyphenyl)propyl acetate

生成物 1

HCID 213220152-(3-Acetyl-4-hydroxyphenyl)propan-1-ol収率 72%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

2-(3-Acetyl-4-hydroxyphenyl)propyl acetate (20.0g; 0.0847 mol) and sodium bicarbonate (25.4g; 0.31 mol) were dissolved in ethanol (200 ml) and water (150 ml), and the mixture was refluxed for 20 hours. Ethanol was removed in vacuo and the residue was extracted with ether (3 × 150 ml). The combined ether extracts were washed with water, saturated sodium bicarbonate solution, brine, and then dried over magnesium sulphate. The product, after removing solvent, was chromatographed on silica gel using ether as eluent to give a pale brown oil (15.0g; 72% yield).

後処理

  1. customEthanol was removed in vacuo
  2. extractionthe residue was extracted with ether (3 × 150 ml)
  3. washThe combined ether extracts were washed with water, saturated sodium bicarbonate solution, brine
  4. dry with materialdried over magnesium sulphate
  5. customThe product, after removing solvent
  6. customwas chromatographed on silica gel
  7. customto give a pale brown oil (15.0g; 72% yield)

出典と根拠

ORDレコード
ord-136bdf3970c64e32858c8a7129b583d6
出典データセット
uspto-grants-1977_11
特許番号
US04057641

関連ノート

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