Methoxycarbonyl isothiocyanate → HCID 54270269、化合物

HRID 1439790ノート

反応式

HRID 1439790 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[C:21]([N:25]=[C:26]=[S:27])([O:23][CH3:24])=[O:22]>C(OCC)C>[C:21]([NH:25][C:26](=[S:27])[NH:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6])([O:23][CH3:24])=[O:22]

参加物

4

反応物 2

HCID 552246Methoxycarbonyl isothiocyanateHCID 54315355HCID 54315355、化合物

生成物 1

HCID 54270269HCID 54270269、化合物収率 10.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 3-amino-4-n-butylaminobenzophenone (2.38 g.) in diethyl ether (200 ml.) is added carbomethoxy isothiocyanate (1.4 g.). The reaction mixture is stirred at room temperature for 3 hours. The product is collected by filtration and dried to afford 0.2 g. of product, m.p. 160°-162° C., dec. The filtrate is allowed to stand overnight at room temperature and a second crop is collected amounting to 0.15 g., m.p. 162° C., dec. The total amount of 3-(3-carbomethoxythioureido)-4-n-butylamino-benzophenone obtained is 0.35 g. (10.2% yield).

後処理

  1. filtrationThe product is collected by filtration
  2. customdried
  3. customto afford 0.2 g
  4. waitto stand overnight at room temperature
  5. customa second crop is collected amounting to 0.15 g

出典と根拠

ORDレコード
ord-6a8fffea90a34df1901b4f30c9d63e2e
出典データセット
uspto-grants-1977_11
特許番号
US04060636

反応ノート

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