8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone

HRID 1439885ノート

反応式

HRID 1439885 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([OH:19])[CH2:18][CH2:17][C:12]3(OCC[O:13]3)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8]>CC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([OH:19])[CH2:10][CH2:11][C:12](=[O:13])[CH2:17][CH2:18]2)[CH:5]=[CH:6][C:7]=1[F:8]

参加物

3

反応物 1

HCID 221221048-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

生成物 1

HCID 221220904-(3,4-Difluorophenyl)-4-hydroxycyclohexanone収率 62%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 8-(3,4-difluorophenyl)-1,4- dioxaspiro[4.5]decan-8-ol (5.4 g, 20 mmole) in acetone-1N hydrochloric acid (1:1) was stirred for 4 hr. The acetone was removed in vacuo and the crude material crystallized from isopropyl ether to give the product (62%, mp: 84°-85° C.).

後処理

  1. customThe acetone was removed in vacuo
  2. customthe crude material crystallized from isopropyl ether

出典と根拠

ORDレコード
ord-c8733dd8ddab41caa8b4f38d885386c9
出典データセット
uspto-grants-1996_03
特許番号
US05496847

反応ノート

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