(1-Phenylcyclopentyl)methanamine → (1-Phenylcyclopentyl)methyl-3-(2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl)urea

HRID 1439928

反応式

HRID 1439928 の反応式
[C:1]1([C:7]2([CH2:12][NH2:13])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14][C:15]1([CH3:28])[CH2:19][C:18]2[CH:20]=[CH:21][C:22]([CH3:27])=[C:23]([N:24]=[C:25]=[O:26])[C:17]=2[O:16]1>C(OCC)(=O)C>[C:1]1([C:7]2([CH2:12][NH:13][C:25]([NH:24][C:23]3[C:17]4[O:16][C:15]([CH3:14])([CH3:28])[CH2:19][C:18]=4[CH:20]=[CH:21][C:22]=3[CH3:27])=[O:26])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 205131(1-Phenylcyclopentyl)methanamineHCID 189850842,2,6-Trimethyl-2,3-dihydrobenzofuran-7-yl isocyanate

生成物 1

HCID 22078692(1-Phenylcyclopentyl)methyl-3-(2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl)urea

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A 60 mg amount of (1-phenycyclopentyl)methylamine was added to a solution of 70 mg of 2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl isocyanate in 2 ml of ethyl acetate, and the mixture was stirred at room temperature for 15 hrs. The solvent was removed by evaporation under reduced pressure, and the residue was subjected to recrystallization to provide 65 mg of the intended title compound.

後処理

  1. customThe solvent was removed by evaporation under reduced pressure
  2. customthe residue was subjected to recrystallization

出典と根拠

ORDレコード
ord-cdba0ed79de547ddb1a2cc12c0538a35
出典データセット
uspto-grants-1996_03
特許番号
US05496853

関連ノート

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