Ethyl Acetate → 6-O-acetylglucal

HRID 1439987ノート

反応式

HRID 1439987 の反応式
[O:1]1[C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]([OH:5])[CH:3]=[CH:2]1.[C:11](OCC)(=[O:13])[CH3:12]>C(OC=C)(=O)C>[C:11]([O:10][CH2:9][C@H:8]1[O:1][CH:2]=[CH:3][C@@H:4]([OH:5])[C@@H:6]1[OH:7])(=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 8857Ethyl AcetateHCID 2734736D-(+)-Glucal

生成物 1

HCID 100476776-O-acetylglucal収率 85%

試薬・触媒・溶媒 1

HCID 7904Vinyl Acetate溶媒

実験手順

1.022 g (7 mmol) of glucal are taken up in 2 ml of ethyl acetate and 30 ml of vinyl acetate, 400 mg of lipase from Candida cylindracea lipase OF (Meito Sangyo Co. Ltd.) are added, and the mixture is stirred at room temperature overnight. After the reusable enzyme has been separated off, and subsequent chromatography or crystallization, 1.12-1.25 g of 6-O-acetylglucal (85-95% yield) are obtained.

後処理

  1. customAfter the reusable enzyme has been separated off

出典と根拠

ORDレコード
ord-622e017256974e258a44c833953015fa
出典データセット
uspto-grants-1996_03
特許番号
US05496930

反応ノート

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