Ammonia → 2',3'-Didehydro-3'-deoxy-4-thiothymidine
反応式
C([O:4][CH2:5][C@H:6]1[O:10][C@@H:9]([N:11]2[CH:19]=[C:17]([CH3:18])[C:15](=[S:16])[NH:14][C:12]2=[O:13])[CH:8]=[CH:7]1)(=O)C.N>CO>[C@@H:9]1([N:11]2[CH:19]=[C:17]([CH3:18])[C:15](=[S:16])[NH:14][C:12]2=[O:13])[O:10][C@H:6]([CH2:5][OH:4])[CH:7]=[CH:8]1参加物
4
実験手順
To 100 mg of the compound synthesized in Example 9, 10 mL of methanol are added, which had been saturated at 0° C. with ammonia. The reaction mixture is kept for 12 hours at room temperature and then evaporated to dryness. Crystals, melting at 117° C.-118° C., are obtained from methanol/ether.
後処理
- customevaporated to dryness
- customCrystals, melting at 117° C.-118° C., are obtained from methanol/ether
出典と根拠
- ORDレコード
- ord-71df7d1b7df54b8baf4c1471c31c5f27
- 出典データセット
- uspto-grants-1996_03
- 特許番号
- US05496935
反応ノート
読み込み中…