1-Octanol → Octyl 2-pyrazinecarboxylate

HRID 1440017ノート

反応式

HRID 1440017 の反応式
[CH2:1]([OH:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[N:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[C:16](O)=[O:17]>S(=O)(=O)(O)O>[N:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[C:16]([O:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[O:17]

参加物

4

反応物 2

HCID 9571-OctanolHCID 10472-Pyrazinecarboxylic acid

生成物 1

HCID 465427Octyl 2-pyrazinecarboxylate収率 88.2%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

A four-necked flask was charged with 426 g (3.271 mole) of 1-octanol, 100 g (0.806 mole) of pyrazinecarboxylic acid and 5.0 g (0.05 mole) of concentrated sulfuric acid and the internal temperature was maintained under stirring at 97°-100° C. for 8 hours. The reaction mixture was then cooled and transferred to a separatory funnel, in which it was washed with two portions, or a total of 330 g, of 8% aqueous solution of sodium carbonate. The oil layer which separated was washed with water and subjected to distillation under reduced pressure to give 168 g of octyl pyrazinecarboxylate. Yield: 88% (based on pyrazinecarboxylic acid).

後処理

  1. temperaturethe internal temperature was maintained
  2. temperatureThe reaction mixture was then cooled
  3. customtransferred to a separatory funnel, in which it
  4. washwas washed with two portions
  5. customThe oil layer which separated
  6. washwas washed with water
  7. distillationsubjected to distillation under reduced pressure

出典と根拠

ORDレコード
ord-4f7955ab85834912a611039ed6dd0492
出典データセット
uspto-grants-1996_03
特許番号
US05496949

反応ノート

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