Water → N-Chloro-4-methoxybenzamide

HRID 1440319ノート

反応式

HRID 1440319 の反応式
[CH3:1][O:2][C:3]1C=CC(C=NO)=[CH:5][CH:4]=1.[Cl:12][N:13]1[C:17](=[O:18])[CH2:16][CH2:15][C:14]1=O.O>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:16]([C:17]([NH:13][Cl:12])=[O:18])=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 94712N-[(4-Methoxyphenyl)methylidene]hydroxylamine

生成物 1

HCID 21579386N-Chloro-4-methoxybenzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Dissolved in 65 ml of dimethylformamide were 6.5 g (43 mmol) of 4-methoxybenzaldoxime, followed by the gradual addition of 6.3 g (47 mmol) of N-chlorosuccinimide at room temperature. After the resultant mixture was stirred for 3 hours, 300 ml of water were added to the reaction mixture. The mixture thus formed was extracted with ethyl ether. The ether layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4-methoxybenzhydroxamic acid chloride was obtained.

後処理

  1. customThe mixture thus formed
  2. extractionwas extracted with ethyl ether
  3. washThe ether layer was washed with saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-3bc455b150ee4fd7b1cd8537b67911ea
出典データセット
uspto-grants-1996_03
特許番号
US05498619

反応ノート

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