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Triethylamine → Methyl 2-pentanoylaminothiophene-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Valeryl chloride | HCID 61186 | — |
| 反応物 | Methyl 2-amino-3-thenoate | HCID 78381 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | Methyl 2-pentanoylaminothiophene-3-carboxylate | HCID 18982094 | 96% |
反応手順
Valeryl chloride (1.3 g) was added to a solution of methyl 2-aminothiophene-3-carboxylate (1.6 g) [Y. Kuwada et al. Chem. Abst. 82, 156252(1975)] and triethylamine (1.2 g) in dichloroethane (20 ml) under ice-cooling. The mixture was stirred for two hours. The reaction mixture was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled under reduced pressure. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (2.3 g, 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05500427 |
| 出典データセット | uspto-grants-1996_03 |
| ORD ID | ord-a8d80564f5a44863b04abaf178b07cb0 |
| 出典メモ | uspto-grants-1996_03 |