O-Methyltyramine → HCID 18982108、化合物

HRID 1440883ノート

反応式

HRID 1440883 の反応式
[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4](SC)[N:3]=1.[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH2:21])=[CH:17][CH:16]=1>O>[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4]([NH:21][CH2:20][CH2:19][C:18]2[CH:22]=[CH:23][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)[N:3]=1

参加物

4

反応物 2

HCID 4657O-MethyltyramineHCID 3276844,6-Pyrimidinediamine, 2-(methylthio)-5-nitroso-

生成物 1

HCID 18982108HCID 18982108、化合物収率 84%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The starting material was prepared as follows:-1) A mixture of 4,6-diamino-2-methylthio-5-nitrosopyrimidine (10 g, 5.4 mM), 4-methoxyphenethylamine (7.92 ml, 5.4 mM) and water (180 ml) was heated to reflux for one hour. After cooling the red solid was separated by filtration, washed with water, and dried. There was thus obtained 4,6-diamino-2-[2-(4-methoxyphenyl)-ethyl]amino-5-nitrosopyrimidine (13.4 g, 84% yield). NMR: DMSO-d6 ; 2.7-2.85(m,2H, CH2 --CH2), 3.4-3.6(m, 2H, CH2 --NH), 3.7 (s, 3H, OCH3), 6.75-6.8(m,2H, aromatic-H), 7.05-7.25 (m, 2H, aromatic-H), 7.4-10.5 (m,5H, NH2 ×2, NH), m/e [M+H[+ 289.

後処理

  1. customThe starting material was prepared
  2. temperaturewas heated
  3. temperatureto reflux for one hour
  4. temperatureAfter cooling the red solid
  5. customwas separated by filtration
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-3a30147a0f8b49088dbc06ba2cc25cbe
出典データセット
uspto-grants-1996_03
特許番号
US05500428

反応ノート

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