Hydrochloric Acid → Ecgonine methyl ester

HRID 1440977ノート

反応式

HRID 1440977 の反応式
[CH3:1][N:2]1[C@H:6]2[C@@H:7]([C:19]([O:21][CH3:22])=[O:20])[C@@H:8]([O:10]C(C3C=CC=CC=3)=O)[CH2:9][C@@H:3]1[CH2:4][CH2:5]2.Cl.Cl>O>[CH3:1][N:2]1[C@H:6]2[C@@H:7]([C:19]([O:21][CH3:22])=[O:20])[C@@H:8]([OH:10])[CH2:9][C@@H:3]1[CH2:4][CH2:5]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 656832(-)-Cocaine hydrochloride

生成物 1

HCID 104904Ecgonine methyl ester

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Cocaine hydrochloride (2.0 g) was dissolved in distilled water (100 ml) and concentrated hydrochloric acid (8.0 ml) and refluxed for 19 hours. After cooling to room temperature, the benzoic acid precipitated and was filtered. The filtrate was washed with chloroform to remove any remaining benzoic acid. The aqueous solution was evaporated to dryness in vacuo. The residue (ecgonine hydrochloride) was esterified by refluxing in methanolic hydrogen chloride (150 ml) for 17 hours. The solvent was removed in vacuo to yield ecgonine methyl ester as an oil.

後処理

  1. customthe benzoic acid precipitated
  2. filtrationwas filtered
  3. washThe filtrate was washed with chloroform
  4. customto remove any remaining benzoic acid
  5. customThe aqueous solution was evaporated to dryness in vacuo
  6. temperatureby refluxing in methanolic hydrogen chloride (150 ml) for 17 hours
  7. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-28ec9451232f47f78445d3a22fdfc220
出典データセット
uspto-grants-1996_03
特許番号
US05501985

反応ノート

読み込み中…