2-Aminobenzonitrile → HCID 18981312、化合物
反応式
N[C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1C(O)[CH2:13][CH:12]([OH:17])[CH2:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.C(#N)C1[C:20](=CC=CC=1)[NH2:21]>>[O:17]=[C:12]1[CH2:11][CH2:10][CH2:15][C:2]([C:3]2[C:8]([NH2:9])=[C:7]([CH:6]=[CH:5][CH:4]=2)[C:20]#[N:21])=[CH:13]1参加物
3
実験手順
To gain entry into the 9-amino-1,2,3,4-tetrahydroacridin-1,3-diol series, i.e., to prepare diols of formula 15, an anthranilonitrile 10 is condensed with a 5-(phenyldialkylsilyl)-1,3-cyclohexanedione 11 to afford a 3-(oxocyclohex-1-enyl)-2-aminobenzonitrile 12, which is cyclized to a 9-amino-3-(phenyldialkylsilyl)acridinone 13 and, in turn, convened to a 9-amino-3-hydroxyacridinone 14 and reduced to a diol 15.
出典と根拠
- ORDレコード
- ord-cbcc7972dc104372bb4fca3ffbc007a1
- 出典データセット
- uspto-grants-1996_03
- 特許番号
- US05502203
反応ノート
読み込み中…