Acetic Acid → 2,6-Diisopropylphenyl acetate

HRID 1441136

反応式

HRID 1441136 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[OH:13])([CH3:3])[CH3:2].[C:14](O)(=[O:16])[CH3:15]>FC(F)(F)C(OC(=O)C(F)(F)F)=O.C(OCC)(=O)C>[C:14]([O:13][C:5]1[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=[CH:7][C:6]=1[CH:10]([CH3:12])[CH3:11])(=[O:16])[CH3:15]

参加物

5

反応物 2

HCID 176Acetic Acid2 回HCID 4943Propofol

生成物 1

HCID 5960912,6-Diisopropylphenyl acetate

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 9845Trifluoroacetic anhydride溶媒

実験手順

A suspension of 2,6-diisopropylphenol (5.32 g) in 35 ml of trifluoroacetic anhydride is treated with 1.75 ml of glacial acetic acid under a nitrogen atmosphere. Upon completion of the addition of acetic acid, the solids are in mixture. Solvent evaporation gives an oil which is taken up in 150 ml of ethyl acetate and washed twice with saturated aqueous sodium bicarbonate and once with saline. Drying of the organic layer with sodium sulfate followed by filtration and solvent evaporation gives 6.55 g of an oil which is chromatographed on 330 g of silica gel eluting with chloroform/hexane (9/1). The appropriate fractions are pooled and concentrated to give the title compound, NMR (CDCl3, TMS) 7.2, 2.91, 2.36, 1.20.

後処理

  1. customSolvent evaporation
  2. customgives an oil which
  3. washwashed twice with saturated aqueous sodium bicarbonate and once with saline
  4. dry with materialDrying of the organic layer with sodium sulfate
  5. filtrationfollowed by filtration and solvent evaporation

出典と根拠

ORDレコード
ord-47a25cf48a2a45d784aaad5f48237b27
出典データセット
uspto-grants-1996_03
特許番号
US05502187

関連ノート

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