Acetyl chloride → (2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

HRID 1441360ノート

反応式

HRID 1441360 の反応式
[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1.[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([N:6]1[CH2:7][C@H:2]([CH3:1])[N:3]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH2:4][C@H:5]1[CH3:8])(=[O:20])[CH3:19]

参加物

3

反応物 2

HCID 6367Acetyl chlorideHCID 57664370(2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

生成物 1

HCID 68686760(2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

実験手順

The title compound was prepared from (2S,5R)-2,5-dimethyl-1-(4-nitrophenyl)piperazine (Method 28, 8.22 g, 34.95 mmol) and acetyl chloride (4.5 ml, 62.91) by the procedure of Method 26. It was obtained as an oil which solidified on standing overnight (11.39 g, >100%, contaminated with solvent) NMR (400 MHz) 1.13 (m, 6H), 3.07 (m, 1H), 3.33 (m, 1H), 3.68 (m, 1H), 4.25 (m, 2H), 4.69 (m, 1H), 7.00 (d, 2H), 8.05 (d, 2H); m/z 278.

後処理

  1. customIt was obtained as an oil which

出典と根拠

ORDレコード
ord-9c492de619204a849626a739f798695f
出典データセット
uspto-grants-2010_02
特許番号
US07655652B2

反応ノート

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