Cyanamide → HCID 178473863、化合物

HRID 1441361ノート

反応式

HRID 1441361 の反応式
[C:1]([N:4]1[CH2:9][C@H:8]([CH3:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[CH2:6][C@H:5]1[CH3:20])(=[O:3])[CH3:2].[N:21]#[C:22][NH2:23]>>[C:1]([N:4]1[C@H:5]([CH3:20])[CH2:6][N:7]([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:22]([NH2:23])=[NH:21])=[CH:13][CH:12]=2)[C@@H:8]([CH3:10])[CH2:9]1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 9864CyanamideHCID 68686760(2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

生成物 1

HCID 178473863HCID 178473863、化合物

反応条件

温度
95 °C

実験手順

The title compound was prepared from (2R,5S)-1-acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine (Method 30, 6.5 g, 26.29 mmol) and cyanamide (2.43 g, 57.84 mmol) by the procedure of Method 31 and heating for 10 h at 95° C. The bicarbonate salt was dried in vac oven at 60° C. overnight. It was obtained as a solid (10.23 g, >100% contaminated with solvent). M/z 290.

後処理

  1. dry with materialThe bicarbonate salt was dried in vac oven at 60° C. overnight
  2. customIt was obtained as a solid (10.23 g, >100% contaminated with solvent)

出典と根拠

ORDレコード
ord-2fe0c12b1f1b4963ad92e333e3f414af
出典データセット
uspto-grants-2010_02
特許番号
US07655652B2

反応ノート

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