Boronic Acid → 2-Cyclopropylpyrimidine-4-boronic Acid
反応式
Br[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]2[CH2:10][CH2:9]2)[N:3]=1.[BH:11]([OH:13])[OH:12].O1BOBOB1>>[CH:8]1([C:4]2[N:3]=[C:2]([B:11]([OH:13])[OH:12])[CH:7]=[CH:6][N:5]=2)[CH2:10][CH2:9]1参加物
4
実験手順
The title compound was prepared from 4-bromo-2-cyclopropylpyrimidine (WO 00/066566) in 90% yield (25 mmol scale) following the procedure by Li et al. (J. Org. Chem. 2002, 67, 5394-5397). LC-MS suggested that the product was composed of the boronic acid and the trimeric anhydride (sym-boroxine).
出典と根拠
- ORDレコード
- ord-29e1a31173c749d7ab55e28fa1292af5
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07655664B2
反応ノート
読み込み中…