Hydrogen Peroxide → Pyridine, 3-methoxy-, 1-oxide

温度

70 °C

3-Methoxypyridine (20.08 g, 209 mmol) was dissolved in 100 mL of acetic acid. 30% H2O2 (28.3 mL, 275 mmol) was added and the reaction mixture was heated at 70° C. for six h. The cooled reaction mixture was concentrated and the residue dissolved in CH2Cl2 and stirred overnight with 20 g of solid potassium carbonate. The mixture was filtered and concentrated to give compound 762A (25.2 g, 100%) as a light yellow solid which was characterized by 1H NMR and carried on to the next step.

1. customThe cooled reaction mixture
2. concentrationwas concentrated
3. dissolutionthe residue dissolved in CH2Cl2
4. filtrationThe mixture was filtered
5. concentrationconcentrated

ORDレコード

ord-0dc54d9576c84a89970668004a135396

出典データセット

uspto-grants-2010_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07655689B2