関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylenediamine | HCID 3301 | — |
| 反応物 | 2-Amino-5-bromo-4-methylpyridine | HCID 817695 | — |
| 反応物 | HCID 178418546 | HCID 178418546 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 6-Amino-4-methylnicotinonitrile | HCID 9964103 | 87% |
反応手順
A mixture of 5-bromo-4-methyl-pyridin-2-ylamine (500 mg, 2.67 mmol), CuCN (478 mg, 5.34 mmol) and DMA (2 mL) was stirred under nitrogen for 20 h at 170° C. The reaction mixture was cooled and added to 50 mL of a 20% aqueous solution of ethane-1,2-diamine. The layers were separated and the aqueous layer was extracted 3× with EtOAc. The combined organics were washed with water followed by brine and dried over MgSO4. Concentration in vacuo afforded compound 851A (309 mg, 87%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07655689B2 |
|---|
| 出典データセット | uspto-grants-2010_02 |
|---|
| ORD ID | ord-f1cda6e7b855453aba081b91d743fa7d |
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| 出典メモ | uspto-grants-2010_02 |
|---|
