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Hydrochloric Acid → 4-(Benzyloxy)-2-chlorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Benzyloxy-2-chloro-benzoic acid ethyl ester | HCID 68420595 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(Benzyloxy)-2-chlorobenzoic acid | HCID 5097985 | 53.1% |
反応手順
17.7 g (60.9 mmol) of 4-benzyloxy-2-chloro-benzoic acid ethyl ester and 4.87 g (122 mmol) of sodium hydroxide were added to a mixed solvent consisting of 180 mL of methanol and 18 mL of water followed by refluxing for 6 hours. After cooling, concentrated hydrochloric acid was added to bring to a pH of 5 followed by filtering out the precipitate. The precipitate was washed with water and dried to obtain 8.5 g of a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07658979B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-c8d03409c3244c96a95fcf0e2f0e78e4 |
| 出典メモ | uspto-grants-2010_02 |