2,3,5-Trifluorobenzaldehyde → 2-[Bis(cyclopropylmethyl)amino]-3,5-difluorobenzaldehyde
反応式
F[C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[CH:12]1([CH2:15][NH:16][CH2:17][CH:18]2[CH2:20][CH2:19]2)[CH2:14][CH2:13]1.C1(CNCC)CCCC1>>[CH:12]1([CH2:15][N:16]([CH2:17][CH:18]2[CH2:20][CH2:19]2)[C:2]2[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=2[CH:4]=[O:5])[CH2:14][CH2:13]1参加物
4
実験手順
By using 2,3,5-trifluorobenzaldehyde instead of 2-fluoro-5-(trifluoromethyl)benzaldehyde, and N,N-bis(cyclopropylmethyl)amine synthesized by the method described in International Patent Publication WO2006/073973 instead of N-(cyclopentylmethyl)-N-ethylamine, reactions and treatments were performed in the same manner as those of Step 3 of Example 1 to obtain 2-[bis(cyclopropylmethyl)amino]-3,5-difluorobenzaldehyde as a yellow oil.
後処理
- customsynthesized by the method
出典と根拠
- ORDレコード
- ord-1c44551e5365410ba8aadd71b3bf484e
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07659271B2
反応ノート
読み込み中…