Hydrochloric Acid → 1,4-Diethynylbenzene

To a 250 mL backed two-necked flask were added 2.36 g (10 mmol) of 1,4-dibromobenzene, 20 mg of Cul and 280 mg or dichlorobis(triphenylphosphine) palladium(ii) [Pd(Ph3P)2Cl2]. Then 38 mL of dried Et3N was injected in under nitrogen and magnetic stirring. Yellow turbidious dispersion was formed immediately. Following by adding 3.6 mL (2.45 g, 25 mmol) of trimethylsilylacetylene. The colour was changed from yellow to deep brown. Stirring was continued at room temperature for 24 hours. A mixture of grey precipitate was formed. The precipitate was separated and washed with Et3N slowly until its colour became white. The Et3N solutions were collected and the solvent was removed. A black solid with some crystal-like substance was obtained. The crude product was purified through a silica gel column using hexane and dichloromethane (1:1 v/v) as eluent. The thus obtained 1,4-bis(trimethylsilylacetyl)benzene (2.25 g, 8.3 mmol) was refluxed with 5.73 g (102 mmol) of KOH in 143 mL ethanol for 6 hours. The solution was poured to 880 mL of 1 M HCl solution. Some yellow flocculates were formed, which were collected and dried. The crude product was further purified by sublimation at 90-100° C. A white powdery product 1,4-diethynylbenzene was obtained in 39% yield.

1. customYellow turbidious dispersion was formed immediately
2. additionA mixture of grey precipitate
3. customwas formed
4. customThe precipitate was separated
5. washwashed with Et3N slowly until its colour
6. customThe Et3N solutions were collected
7. customthe solvent was removed
8. customA black solid with some crystal-like substance was obtained
9. customThe crude product was purified through a silica gel column
10. customSome yellow flocculates were formed
11. customwhich were collected
12. customdried
13. customThe crude product was further purified by sublimation at 90-100° C

ORDレコード

ord-8df696899936403cb7c73314cf91474c

出典データセット

uspto-grants-2010_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07659353B2