Methanesulfonate → (R)-2-[(S)-(Benzofuran-6-yloxy)-phenyl-methyl]-morpholine

反応式

C(OC([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH:14]([OH:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9]1)=O)(C)(C)C.O[C:23]1[CH:31]=[CH:30][C:26]2[CH:27]=[CH:28][O:29][C:25]=2[CH:24]=1.S([O-])(=O)(=O)C>>[O:29]1[C:25]2[CH:24]=[C:23]([O:21][C@@H:14]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C@@H:10]3[O:11][CH2:12][CH2:13][NH:8][CH2:9]3)[CH:31]=[CH:30][C:26]=2[CH:27]=[CH:28]1

参加物

反応物 3

HCID 85257Methanesulfonate

HCID 1288446-Hydroxybenzofuran

HCID 600510212-(Hydroxy-phenyl-methyl)-morpholine-4-carboxylic acid tert-butyl ester

生成物 1

HCID 68541124(R)-2-[(S)-(Benzofuran-6-yloxy)-phenyl-methyl]-morpholine

実験手順

(R)-2-[(S)-(Benzofuran-6-yloxy)-phenyl-methyl]-morpholine was synthesized from 2-(Hydroxy-phenyl-methyl)-morpholine-4-carboxylic acid tert-butyl ester and 6-hydroxybenzofuran according General Procedure C employing the alternate etherification sequence (via the mesylate) and was isolated as an oil. MS (APCI): 310 [M+H]+.

後処理

customwas isolated as an oil

出典と根拠

ORDレコード: ord-bd8daf2d111f45cf84c4b59e6ac87810
出典データセット: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07659394B2

反応ノート

読み込み中…