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2-Bromo-1-(2,5-dichlorophenyl)ethanone → 1-Benzo[1,3]dioxol-4-yl-2-bromo-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-1-(2,5-dichlorophenyl)ethanone | HCID 2756907 | — |
| 反応物 | 1-(1,3-Dioxaindan-4-yl)ethan-1-one | HCID 13731006 | — |
| 生成物 | 1-Benzo[1,3]dioxol-4-yl-2-bromo-ethanone | HCID 21864977 | 48% |
反応手順
This compound was prepared from 1-benzo[1,3]dioxol-4-yl-ethanone (2.15 g, 13.1 mmol) in the manner described for 2-bromo-1-(2,5-dichlorophenyl)ethanone (Example I-2), affording 1.54 g (48%) of 1-benzo[1,3]dioxol-4-yl-2-bromo-ethanone as an off-white solid. 1H-NMR (CD2Cl2) δ; 7.41 (dd, J=8.1 Hz, 1H), 7.05 (dd, J=8.1 Hz, 1 H), 6.94 (dd, J=8.8 Hz, 1H), 6.13 (s, 2H), 4.55 (s, 2H). TLC Rf=0.28, 15%, ethyl acetate-hexanes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07659412B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-5143ea45ae794d5a947696bd090bb286 |
| 出典メモ | uspto-grants-2010_02 |