HCID 178439403、化合物 → CID 57687148

HRID 1443491ノート

反応式

HRID 1443491 の反応式
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[C:5]([CH3:15])[C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.[CH:16]([C:19]1[CH:23]=[CH:22][NH:21][N:20]=1)([CH3:18])[CH3:17]>>[OH:12][C:10]1[C:9]2[C:4](=[C:5]([CH3:15])[C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=[C:2]([N:21]2[CH:22]=[CH:23][C:19]([CH:16]([CH3:18])[CH3:17])=[N:20]2)[N:11]=1

参加物

3

反応物 2

HCID 178439403HCID 178439403、化合物HCID 1784877522-chloro-7-methoxy-8-methyl-1H-quinazolin-4-one

生成物 1

HCID 178487760CID 57687148収率 63.4%

反応条件

温度
155 °C

実験手順

A mixture of 2-chloro-4-hydroxy-7-methoxy-8-methylquinazoline (140) (502 mg, 2.23 mmol) and 3-isopropylpyrazole (500 mg, 4.55 mmol) was heated at 155° C. for 10 min. Then, the reaction mixture was successively cooled down to room temperature, partitioned between CH2Cl2 and water, dried (Na2SO4) and evaporated. The residue was triturated in ether and filtered to give the title compound (422 mg, 63%) as white needles: m/z=299 (M+H)+.

後処理

  1. temperatureThen, the reaction mixture was successively cooled down to room temperature
  2. custompartitioned between CH2Cl2 and water
  3. dry with materialdried (Na2SO4)
  4. customevaporated
  5. customThe residue was triturated in ether
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-bbfde6ba36554b468815b89bebe5adab
出典データセット
uspto-grants-2010_02
特許番号
US07659245B2

反応ノート

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