1-Benzyl-3-trimethylsilyloxy-azetidine → 1-benzylazetidin-3-ol

HRID 1443762ノート

反応式

HRID 1443762 の反応式
[CH2:1]([N:8]1[CH2:11][CH:10]([O:12][Si](C)(C)C)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+]>CO>[CH2:1]([N:8]1[CH2:11][CH:10]([OH:12])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 38004681-Benzyl-3-trimethylsilyloxy-azetidineHCID 10942334Sodium Methoxide

生成物 1

HCID 38013451-benzylazetidin-3-ol収率 77.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-Benzyl-3-trimethylsilyloxy-azetidine (1.8 g, 7.65 mmol) prepared in preparation example 25 was dissolved in methanol (9 ml), sodium methoxide (826 mg, 15.29 mmol) was added thereto, and stirred at room temperature for 30 min. The solvent was removed by evaporation under a reduced pressure, and the residue was extracted using ethyl acetate. The organic extract layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure, to obtain 0.964 g (yield: 77%) of the title compound.

後処理

  1. customThe solvent was removed by evaporation under a reduced pressure
  2. extractionthe residue was extracted
  3. washThe organic extract layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under a reduced pressure

出典と根拠

ORDレコード
ord-99fdf6ae5f874c87a8fd53e869c2f953
出典データセット
uspto-grants-2010_02
特許番号
US07662810B2

反応ノート

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