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3-Aminocinnamic acid ethyl ester → 3-(3-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| 反応物 | 5-(3-Chlorophenyl)furan-2-carboxylic acid | HCID 736256 | — |
| 生成物 | 3-(3-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68490796 | — |
反応手順
Carboxylic acid (65) (58 mg, 0.26 mmol) was coupled to ethyl ester (60) (50 mg, 0.26 mmol) using Method C. The crude residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07662839B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-57635100a5f04ce58e90eeb35e11ad1a |
| 出典メモ | uspto-grants-2010_02 |