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3-Fluorophenylboronic acid → 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| 反応物 | 3-{3-[(6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 72348809 | — |
| 生成物 | 3-(3-{[6-(3-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68497963 | — |
反応手順
The pyridyl bromide (109) (100 mg, 0.27 mmol) was coupled to 3-fluoro-phenylboronic acid (41 mg, 0.29 mmol) using Method E. The residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07662839B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-e63f3ff3c5c548d9b8296336abfb1d2d |
| 出典メモ | uspto-grants-2010_02 |