Ethyl 2-(3-aminophenoxy)acetate → [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester

HRID 1444351

反応式

HRID 1444351 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH2:12]([O:14][C:15](=[O:25])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:25])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[F:11])[CH:19]=1)[CH3:13]

参加物

3

反応物 2

HCID 412308Ethyl 2-(3-aminophenoxy)acetateHCID 27363155-Bromo-2-fluorobenzoic acid

生成物 1

HCID 40356283[3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester

実験手順

5-Bromo-2-fluoro-benzoic acid (250 mg, 1.14 mmol) was coupled to aniline (64) (245 mg, 1.25 mmol) using Method D. The residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.

後処理

  1. customThe residue was purified by column chromatography
  2. washeluting with a stepped gradient of 10-15% EtOAc in heptane

出典と根拠

ORDレコード
ord-e3c279bba8bf4698a6ae01d108be464f
出典データセット
uspto-grants-2010_02
特許番号
US07662839B2

関連ノート

読み込み中…