化工社化工社 化学情報印刷レポート · 研究参考用
3,5-Dichlorophenylboronic acid → (3-[(3',5'-Dichloro-4-fluoro-biphenyl-3-carbonyl)-amino]-phenoxy)-acetic Acid Ethyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dichlorophenylboronic acid | HCID 2734331 | — |
| 反応物 | [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester | HCID 40356283 | — |
| 生成物 | (3-[(3',5'-Dichloro-4-fluoro-biphenyl-3-carbonyl)-amino]-phenoxy)-acetic Acid Ethyl Ester | HCID 59654599 | — |
反応手順
The phenyl bromide (139) (50 mg, 0.13 mmol) was coupled to 3,5-dichloro-phenylboronic acid (24 mg, 0.13 mmol) using method E. The residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07662839B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-5b81d955445148669648793368bd4411 |
| 出典メモ | uspto-grants-2010_02 |