関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Docetaxel | HCID 148124 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | C43H53NO14.3H2O | HCID 24721032 | 328.1% |
反応手順
Docetaxel anhydrous (about 0.8 Kg), acetonitriie (about 3.8 Kg) and glacial acetic acid (about 7.6 g) are charged into a suitable vessel. The mixture is heated to NMT 45° C., and purified process water (about 9.6 Kg) is added for precipitation. The slurry is filtered, washed and dried under a moist environment to provide docetaxel trihydrate (about 0.7 Kg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07662980B2 |
|---|
| 出典データセット | uspto-grants-2010_02 |
|---|
| ORD ID | ord-74b874e7d34f4f6abaf8d5a5fe91c1c1 |
|---|
| 出典メモ | uspto-grants-2010_02 |
|---|
