Methyl 3-(methyl(pentyl)amino)propanoate → N-Methyl-N-pentyl-beta-alanine

HRID 1444845

反応式

HRID 1444845 の反応式
C[O:2][C:3](=[O:13])[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>O>[CH3:12][N:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH2:5][CH2:4][C:3]([OH:13])=[O:2]

参加物

3

反応物 1

HCID 16726422Methyl 3-(methyl(pentyl)amino)propanoate

生成物 1

HCID 16036977N-Methyl-N-pentyl-beta-alanine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

68.8 g (367.4 mmol) N-methyl-N-pentyl-β-alanine methyl ester was hydrolyzed by refluxing with 138 ml water. Water was distilled off and 300 ml diethyl carbonate were added, followed by azeotropic distillation of diethyl carbonate/water (30 ml) to remove residual water. About 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine was obtained which could directly be used for the subsequent bisphosphorylation step.

後処理

  1. distillationWater was distilled off
  2. addition300 ml diethyl carbonate were added
  3. distillationfollowed by azeotropic distillation of diethyl carbonate/water (30 ml)
  4. customto remove residual water
  5. additionAbout 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine
  6. customwas obtained which

出典と根拠

ORDレコード
ord-61203c1e27a947bb92be1994604cf1c6
出典データセット
uspto-grants-2010_02
特許番号
US07662990B2

関連ノート

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