Water → 647833-71-4
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[S:12][CH:13]=[CH:14][C:15]=2[O:16]C)=[O:10])=[CH:5][CH:4]=1.O>ClCCl>[OH:16][C:15]1[CH:14]=[CH:13][S:12][C:11]=1[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:10]参加物
4
実験手順
993 mg of (4-methoxy-phenyl)-(3-methoxy-thiophen-2-yl)-methanone were dissolved in 20 ml of dry dichloromethane, and 7 ml of boron tribromide/dimethyl sulfide complex were added. The mixture was stirred at room temp. until the reaction was complete (TLC check). It was then poured into water and extracted several times with dichloromethane. The organic phase was dried and concentrated, and the residue was purified by column chromatography (SiO2, ethyl acetate/n-heptane=1:4). The product with the molecular weight of 234.3 (C12H10O3S), MS (Cl): 235 (M+H+) was obtained.
後処理
- addition7 ml of boron tribromide/dimethyl sulfide complex were added
- extractionextracted several times with dichloromethane
- customThe organic phase was dried
- concentrationconcentrated
- customthe residue was purified by column chromatography (SiO2, ethyl acetate/n-heptane=1:4)
- customThe product with the molecular weight of 234.3 (C12H10O3S), MS (Cl): 235 (M+H+) was obtained
出典と根拠
- ORDレコード
- ord-7b3c4556084e44a38e2e03868d36fbd6
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07666848B2
反応ノート
読み込み中…