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N-(2-Aminophenyl)-4-methoxybenzamide → N1-[4-Benzyloxy-2-(3-tert-butoxycarbonylaminopropoxy)benzoyl]-N2-(4-methoxybenzoyl)-1,2-benzenediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-Aminophenyl)-4-methoxybenzamide | HCID 785232 | — |
| 反応物 | 4-Benzyloxy-2-(3-tert-butoxycarbonylaminopropoxy)benzoic acid | HCID 68544919 | — |
| 生成物 | N1-[4-Benzyloxy-2-(3-tert-butoxycarbonylaminopropoxy)benzoyl]-N2-(4-methoxybenzoyl)-1,2-benzenediamine | HCID 86628413 | 65.7% |
反応手順
In a manner substantially equivalent to Example 101-D, 4-benzyloxy-2-(3-tert-butoxycarbonylaminopropoxy)benzoic acid (4.98 g, 12.4 mmol) and N1-(4-methoxybenzoyl)-1,2-benzenediamine (3.00 g, 12.4 mmol) were coupled to give 5.10 g (65.7%) of the title compound as a white foam after purification by silica gel (hexanes:EtOAc) chromatography on a Waters prep 500 instrument.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07666866B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-466e023d71f54fbdb6dacc8a6c89da9e |
| 出典メモ | uspto-grants-2010_02 |