Potassium tert-butoxide → 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

反応式

[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15](F)[C:12]([C:13]#[N:14])=[C:11]([F:18])[CH:10]=1.C[C:20](C)([O-:22])C.[K+]>>[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15]([O:22][CH3:20])[C:12]([C:13]#[N:14])=[C:11]([F:18])[CH:10]=1

参加物

反応物 2

HCID 23665647Potassium tert-butoxide

HCID 686919624-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile

生成物 1

HCID 686911704-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

実験手順

The compound was synthesized in the similar manner as in Reference Example 4-1 using 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile and 1 equivalent of potassium tert-butoxide.

出典と根拠

ORDレコード: ord-7b9d1084d72143e69bd75e255f03e409
出典データセット: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07666873B2

反応ノート

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