Phosphorus tribromide → 5-(Bromomethyl)-1-methyl-1H-benzotriazole

HRID 1445625ノート

反応式

HRID 1445625 の反応式
P(Br)(Br)[Br:2].[CH3:5][N:6]1[C:10]2[CH:11]=[CH:12][C:13]([CH2:15]O)=[CH:14][C:9]=2[N:8]=[N:7]1>C(OCC)C.O>[Br:2][CH2:15][C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH3:5])[N:7]=[N:8][C:9]=2[CH:14]=1

参加物

5

反応物 2

HCID 24614Phosphorus tribromideHCID 2776552(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

生成物 1

HCID 27954185-(Bromomethyl)-1-methyl-1H-benzotriazole

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

Phosphorus tribromide (0.230 ml, 2.45 mmol) is added to a stirred solution of (1-methyl-1H-1,2,3-benzotriazole-5-yl)methanol (0.4 g, 2.45 mmol) in diethyl ether (25 ml) under an inert atmosphere of Argon. After stirring overnight at room temperature, the reaction mixture is diluted with water (5 ml) and stirred vigorously for 10 minutes. The organic portion is separated, washed with water (2×5 ml), brine (2×5 ml) and concentrated in vacuo to yield the titled product which is used crude in the next step. (MH+ 226).

後処理

  1. stirringstirred vigorously for 10 minutes
  2. customThe organic portion is separated
  3. washwashed with water (2×5 ml), brine (2×5 ml)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2041352cb9894fd38901573f892bf2ab
出典データセット
uspto-grants-2010_02
特許番号
US07666878B2

反応ノート

読み込み中…