Hydrochloric Acid → 2-Amino-4-(benzyloxy)butanoic acid hydrochloride

反応式

[CH2:1]([O:8][CH2:9][CH2:10][CH:11]([NH:15]C(OC(C)(C)C)=O)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:23].CCOCC>>[ClH:23].[NH2:15][CH:11]([CH2:10][CH2:9][O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:12]([OH:14])=[O:13]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 3283Diethyl Ether

HCID 22458694Boc-DL-hse(bzl)-oh

生成物 1

HCID 686989202-Amino-4-(benzyloxy)butanoic acid hydrochloride

実験手順

In a round bottom flask containing 4-benzyloxy-2-tert-butoxycarbonylamino-butyric acid (1.0 mmol), add 1M hydrochloric acid in ether (1.7 mmol) and stir at room temperature for two days. The product precipitates out as the hydrochloride salt. Collect by centrifugation in which the mother liquor is decanted off of the product. Rinse two times with ether, transfer solid to a flask and concentrate in vacuo.