Triethylamine → 1-benzyl-2-ethyl-1H-pyrrole

HRID 1445937

反応式

HRID 1445937 の反応式
[C:1]1(C2C=CC=CC=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14].C1(C2C=CC=CC=2)C=CC=CC=1CN.C(N(CC)CC)C>C1C=CC=CC=1>[CH2:7]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:1]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2633661-Biphenyl-2-ylmethanamineHCID 591704071-(Biphenyl-2-ylmethyl)-2-ethyl-1h-pyrrole

生成物 1

HCID 32494221-benzyl-2-ethyl-1H-pyrrole

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

1-(biphenyl-2-ylmethyl)-2-ethyl-1H-pyrrole, 13: To the crude 12 (14 g, 83 mmol) in dry benzene (200 mL) at room temperature is added biphenyl-2-ylmethanamine solution (100 mmol) and triethylamine (110 mmol). The solution is heated to reach 65° C. and stirred for 18 h. The resulted reaction mixture is filtered and concentrated. The crude product was purified by silica gel chromatography to afford 13

後処理

  1. temperatureThe solution is heated
  2. customto reach 65° C.
  3. customThe resulted reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated
  6. customThe crude product was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-6aecf2aef7954c0e9158959462e7c8ff
出典データセット
uspto-grants-2010_02
特許番号
US07666898B2

関連ノート

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