Diethylamine → N,N-Diethyl-5-(4-fluorophenyl)isoxazole-4-carboxamide
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH2:16]([NH:18][CH2:19][CH3:20])[CH3:17]>>[CH2:16]([N:18]([CH2:19][CH3:20])[C:13]([C:9]1[CH:10]=[N:11][O:12][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:15])[CH3:17]参加物
3
実験手順
The title compound was prepared from 5-(4-fluorophenyl)isoxazole-4-carboxylic acid (10.4 mg, 0.050 mmol) and diethylamine (4.4 mg, 0.060 mmol) as described in synthetic method A and thereafter purified by preparative HPLC method A to give a solid (11.4 mg). MS (pos) m/z 263.1 (M+1).
後処理
- custompurified by preparative HPLC method A
出典と根拠
- ORDレコード
- ord-a9c474a32c484e5b9c8603f8e9f62aea
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07666888B2
反応ノート
読み込み中…