4-(Trifluoromethoxy)benzylamine → HCID 24809929、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)[CH:5]=[CH:6][CH:7]=1.[F:16][C:17]([F:28])([F:27])[O:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([NH:24][CH2:23][C:22]2[CH:25]=[CH:26][C:19]([O:18][C:17]([F:16])([F:27])[F:28])=[CH:20][CH:21]=2)=[O:15])[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
The title compound was prepared from 5-(3-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 4-(trifluoromethoxy)benzylamine (11.5 mg, 0.060 mmol) as described in synthetic method A and thereafter purified by preparative HPLC method B to give a solid (4.5 mg). MS (pos) m/z 397.0 (M+H).
後処理
- custompurified by preparative HPLC method B
出典と根拠
- ORDレコード
- ord-2e455710aeaf4a9aaf73ac55e9b8362b
- 出典データセット
- uspto-grants-2010_02
- DOI