Vitamin D3 → Ergocalciferol

HRID 1446800ノート

反応式

HRID 1446800 の反応式
[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][CH2:16]/[C:17](=[CH:18]\[CH:19]=[C:20]3\[CH2:21][C@@H:22]([OH:27])[CH2:23][CH2:24][C:25]\3=[CH2:26])/[C@@H:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7].[CH3:29]C(CC(C1C(=O)OC2C=CC=CC=2C=1O)C1C=CC=CC=1)=O>>[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][CH2:16]/[C:17](=[CH:18]\[CH:19]=[C:20]3\[CH2:21][C@@H:22]([OH:27])[CH2:23][CH2:24][C:25]\3=[CH2:26])/[C@@H:12]2[CH2:11][CH2:10]1)/[CH:3]=[CH:4]/[C@@H:5]([CH:6]([CH3:7])[CH3:8])[CH3:29]

参加物

3

反応物 2

HCID 5280795Vitamin D3HCID 54678486Warfarin

生成物 1

HCID 5280793Ergocalciferol

実験手順

The present invention thus provides a highly effective rodenticide preparation. The rodenticide is readily and economically prepared in a five-step sequence which does not require purification of intermediates. The preparation of this rodenticide in about 50% yield from vitamin D combined with its much higher rodenticidal activity (i.e., at least 20-30 times more potent than vitamin D3) make it a preferred agent for rodent control. The preparation should be particularly effective for the control of rats resistant to commercial rodenticides (e.g., warfarin) and is also advantageously used for the control of other rodents (e.g., mice) or other vertebrate pests (e.g., birds). The high potency of the material combined with its delayed onset of action should overcome problems of bait-avoidance or taste rejection encountered with previously known rodenticies.

後処理

  1. customThe present invention thus provides
  2. customa highly effective rodenticide preparation
  3. customeconomically prepared in a five-step sequence which
  4. custompurification of intermediates
  5. customThe preparation of this rodenticide in about 50% yield from vitamin D
  6. customThe preparation

出典と根拠

ORDレコード
ord-d0cd1a3822e24aeea7f82608b29e2292
出典データセット
uspto-grants-1982_02
特許番号
US04313942

反応ノート

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