1H-Imidazole-4-carbaldehyde → Triphenylphosphine Oxide

HRID 1446805ノート

反応式

HRID 1446805 の反応式
[C:1]1([P:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=C(C)C(OC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=C(C=[O:32])N=C1>C(O)C>[C:1]1([P:7](=[O:32])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 764281H-Imidazole-4-carbaldehydeHCID 10569721Methyl 2-(triphenyl-lambda~5~-phosphanylidene)propanoate

生成物 1

HCID 13097Triphenylphosphine Oxide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 0.961 g (10 mmol) of methyl 2-(triphenylphosphoranylidene)propionate [H. J. Bestmann and H. Schulz, Angew. Chem., 73, 27 (1961)] and 3.48 g (10 mmol) of imidazole-4-carboxaldehyde [F. L. Pyman, J. Chem. Soc., 186 (1916)] in 50 ml of absolute ethanol is stirred at room temperature for seven days. At the end of this time, the ethanol is removed in vacuo and the desired product is isolated free of triphenylphosphine oxide by chromatography on silica gel. The product thus obtained is a mixture of E and Z olefin isomers.

後処理

  1. customAt the end of this time, the ethanol is removed in vacuo

出典と根拠

ORDレコード
ord-1fc85ae81581434fba6c6d170ce17949
出典データセット
uspto-grants-1982_02
特許番号
US04313948

反応ノート

読み込み中…