2-Amino-3-benzoyl-5-chloro-α-(methylthio)benzeneacetamide → 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide

HRID 1446826ノート

反応式

HRID 1446826 の反応式
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5]([Cl:16])=[CH:4][C:3]=1[CH:17](SC)[C:18]([NH2:20])=[O:19]>[Ni].C(O)C.CN(C)C=O>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5]([Cl:16])=[CH:4][C:3]=1[CH2:17][C:18]([NH2:20])=[O:19]

参加物

5

反応物 1

HCID 670799562-Amino-3-benzoyl-5-chloro-α-(methylthio)benzeneacetamide

生成物 1

HCID 178767402-AMino-3-benzoyl-5-chlorobenzeneacetaMide

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 702Ethanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 21.34 g (0.0639 mole) of 2-amino-3-benzoyl-5-chloro-α-(methylthio)-phenylacetamide and excess Raney nickel in a mixture of 900 ml of absolute ethanol and 200 ml of dimethylformamide was stirred at room temperature for 45 min. The mixture was filtered through celite to remove the Raney nickel. The solvent was removed in vacuo to give a yellow solid which when recrystallized melted at 213.5°-215.0° C.(d).

後処理

  1. filtrationThe mixture was filtered through celite
  2. customto remove the Raney nickel
  3. customThe solvent was removed in vacuo
  4. customto give a yellow solid which when
  5. customrecrystallized melted at 213.5°-215.0° C.(d)

出典と根拠

ORDレコード
ord-3d4b8b6afa974027b6a4a17c4d914055
出典データセット
uspto-grants-1982_02
特許番号
US04313949

反応ノート

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