Ammonium Hydroxide → 4-(1-Ethyl-1H-imidazol-4-yl)phenol
反応式
[OH-].[NH4+].[CH2:3]([N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[N:7]=[C:6]1S)[CH3:4]>[Ni].C(O)C>[CH2:3]([N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[N:7]=[CH:6]1)[CH3:4]参加物
5
実験手順
To a stirred mixture of 10 parts of Raney-nickel catalyst and 96 parts of ethanol are added successively 9 parts of ammonium hydroxide and 9 parts of 4-(1-ethyl-2-mercapto-1H-imidazol-4-yl)phenol. Stirring is continued for 2 hours at reflux temperature. The reaction mixture is filtered and the filtrate is evaporated. The precipitated product is filtered off, washed with a small amount of a mixture of 2,2'-oxybispropane and ethanol, and dried, yielding 6.7 parts of 4-(1-ethyl-1H-imidazol-4-yl)phenol.
後処理
- temperatureat reflux temperature
- filtrationThe reaction mixture is filtered
- customthe filtrate is evaporated
- filtrationThe precipitated product is filtered off
- washwashed with a small amount of a mixture of 2,2'-oxybispropane and ethanol
- customdried
出典と根拠
- ORDレコード
- ord-b5872854c4694300a61bc1c123356630
- 出典データセット
- uspto-grants-1982_02
- 特許番号
- US04313953
反応ノート
読み込み中…