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n-Methyl-p-aminophenol → 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | n-Methyl-p-aminophenol | HCID 5931 | — |
| 反応物 | 2-Chlorobenzimidazole | HCID 78572 | — |
| 溶媒 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 生成物 | 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol | HCID 13314818 | 58.7% |
反応手順
A mixture of 2-chlorobenzimidazole (1.0 g), 4-(N-methylamino)phenol (1.13 g) and acetonitrile/water (1:1) was heated under reflux for a period of 5 hours. The mixture was concentrated, made basic with dilute ammonium hydroxide and the solid was collected. The product was recrystallised from ethanol to give 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol (0.92 g) as colourless crystals, mp>260° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04314065 |
| 出典データセット | uspto-grants-1982_02 |
| ORD ID | ord-fac870d124ac453eb09f7b0f90d47b6a |
| 出典メモ | uspto-grants-1982_02 |