関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Benzamide, N-cyano- | HCID 84805 | — |
| 反応物 | 2-Guanidino-4-(3-aminophenyl)-thiazole hydrochloride hydrobromide | HCID 178419579 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 178512618 | HCID 178512618 | — |
反応手順
A mixture of 2-guanidino-4-(3-aminophenyl)-thiazole hydrochloride hydrobromide (1.2 g.) and benzoylcyanamide (0.7 g.) in dimethylformamide (15 ml.) and water (10 ml.) was heated at 90° C. for 2 hours. The mixture was diluted with water (30 ml.) and made strongly basic with dilute sodium hydroxide solution. The mixture was extracted with ethyl acetate (2×50 ml.) and the extract evaporated to dryness to give 2-guanidino-4-[3-(2-benzoylguanidino)phenyl]-thiazole as a dark gum (0.9 g.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04315009 |
|---|
| 出典データセット | uspto-grants-1982_02 |
|---|
| ORD ID | ord-6402d85af84c481a80d03f3996c0daa0 |
|---|
| 出典メモ | uspto-grants-1982_02 |
|---|
