5-Bromotryptamine → HCID 13241177、化合物

HRID 1446994

反応式

HRID 1446994 の反応式
[Br:1][C:2]1[CH:13]=[C:12]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][CH2:10][NH2:11])=[CH:4][CH:3]=1.[CH2:14]([CH:16]1[CH2:22][CH2:21][CH2:20][O:19][C:17]1=[O:18])[CH3:15]>C1(C)C(C)=CC=CC=1>[CH2:14]([CH:16]([CH2:22][CH2:21][CH2:20][OH:19])[C:17]([NH:11][CH2:10][CH2:9][C:8]1[C:12]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:13]=2)[NH:6][CH:7]=1)=[O:18])[CH3:15]

参加物

4

反応物 2

HCID 771585-BromotryptamineHCID 36563182H-Pyran-2-one, 3-ethyltetrahydro-

生成物 1

HCID 13241177HCID 13241177、化合物収率 80%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

0.48 g. (2.0 mmoles) of 5-bromo-tryptamine and 0.30 g. (2.3 mmoles) of 2-ethyl-pentanolide are dissolved in 5 ml. of abs. xylene, and the solution is refluxed for 4 hours. The reaction mixture is evaporated in vacuo, the residue is triturated twice with 3 ml. each of petroleum ether, thereafter it is dried in a desiccator. 0.59 g. (80%) of N-(α-ethyl-δ-hydroxy-valeroyl)-5-bromo-tryptamine are obtained.

後処理

  1. customThe reaction mixture is evaporated in vacuo
  2. customthe residue is triturated twice with 3 ml
  3. dry with materialeach of petroleum ether, thereafter it is dried in a desiccator

出典と根拠

ORDレコード
ord-714ca3903f054c399b0c7d7391711205
出典データセット
uspto-grants-1982_02
特許番号
US04315011

関連ノート

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